12-lipoxygenase in porcine coronary microcirculation: implications for coronary vasoregulation.

  title={12-lipoxygenase in porcine coronary microcirculation: implications for coronary vasoregulation.},
  author={Martina Zink and Christine L. Oltman and Tong Lu and Prasad Venkateswera Gurunath Katakam and Terry L. Kaduce and Hon-chi Lee and Kevin C. Dellsperger and Arthur A. Spector and Paul R. Myers and Neal L. Weintraub},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={280 2},
Noncyclooxygenase metabolites of arachidonic acid (AA) have been proposed to mediate endothelium-dependent vasodilation in the coronary microcirculation. Therefore, we examined the formation and bioactivity of AA metabolites in porcine coronary (PC) microvascular endothelial cells and microvessels, respectively. The major noncyclooxygenase metabolite produced by microvascular endothelial cells was 12(S)-hydroxyeicosatetraenoic acid (HETE), a lipoxygenase product. 12(S)-HETE release was markedly… CONTINUE READING


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