12-O-tetradecanoylphorbol-13-acetate-induced apoptosis is mediated by tumor necrosis factor alpha in human monocytic U937 cells.

@article{Takada199912Otetradecanoylphorbol13acetateind,
  title={12-O-tetradecanoylphorbol-13-acetate-induced apoptosis is mediated by tumor necrosis factor alpha in human monocytic U937 cells.},
  author={Yoshio Takada and Misao Hachiya and Yoshiaki Osawa and Yutaka Hasegawa and Kiyohiro Ando and Yoshinori Kobayashi and Makoto Akashi},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 40},
  pages={
          28286-92
        }
}
12-O-tetradecanoylphorbol-13-acetate (TPA), a phorbol ester that is known as a tumor promoter, induces differentiation of myeloid cells and suppresses their proliferation. We studied the regulation of apoptosis by TPA in human monocytic cell line U937 cells that lack p53. Untreated U937 cells constitutively underwent apoptosis, and TPA enhanced apoptosis in these cells. Further studies showed that TPA increased production of tumor necrosis factor-alpha (TNFalpha) in U937 cells, and exogenously… CONTINUE READING

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