12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells.

  title={12-Lipoxygenase inhibition induced apoptosis in human gastric cancer cells.},
  author={Benjamin Chun-yu Wong and Wei Wang and Chi-hin Cho and Xiaopeng Fan and Marie C. Lin and Hsiang Fu Kung and Shiu Kum Lam},
  volume={22 9},
Arachidonic acid release from membrane phospholipids is essential for tumour cell proliferation. Lipoxygenases constitute a pathway for arachidonate metabolism. The present study investigated the expression of 12-lipoxygenase and its effect on cell proliferation as well as survival in two human gastric cancer cell lines (AGS and MKN-28). RT-PCR and western blots, respectively, showed 12-LOX mRNA and protein expression in both AGS and MKN-28 cell lines. Treatment with a 12-LOX inhibitor… CONTINUE READING