12 Group III Metabotropic Glutamate Receptors ( mGlu 4 , mGlu 6 , mGlu 7 , and mGlu 8 )

@inproceedings{Neugebauer200812GI,
  title={12 Group III Metabotropic Glutamate Receptors ( mGlu 4 , mGlu 6 , mGlu 7 , and mGlu 8 )},
  author={Volker Neugebauer},
  year={2008}
}
G protein-coupled group III metabotropic glutamate receptors (mGluRs) include four subtypes that are negatively coupled to adenylyl cyclase (mGluRs 4, 7, and 8) or positively to a cGMP phosphodiesterase (mGluR6). Typically, they exert inhibitory influences on neuronal activity. This chapter reviews the characteristics of group III mGluRs and their normal functions and role in nervous system disorders. The therapeutic potential of group III mGluRs resides in their antiepileptic (mGluRs 4 and 7… CONTINUE READING