12 Cytokine-Induced-Cell Stress and Death in Type 1 Diabetes Mellitus

@inproceedings{Vincenz201212CS,
  title={12 Cytokine-Induced-Cell Stress and Death in Type 1 Diabetes Mellitus},
  author={Lisa Vincenz and Eva Szegezdi and Richard J{\"a}ger and Caitriona Holohan and Timothy J. O’Brien and Afshin Samali},
  year={2012}
}
1.1 Pathophysiology of type I diabetes mellitus: Role of pro-inflammatory cytokines Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterised by the destruction of insulin-producing ┚-cells in the pancreatic islets of Langerhans (Fig.1), which is mediated by autoreactive T cells, macrophages and pro-inflammatory cytokines (Fig.2). This leads to an inability to produce sufficient insulin resulting in elevated blood glucose levels and pathological effects (Eizirik & Mandrup-Poulsen… CONTINUE READING