12/15-Lipoxygenase Contributes to Platelet-derived Growth Factor-induced Activation of Signal Transducer and Activator of Transcription 3*

Abstract

We showed previously that the small molecule indirubin-3'-monoxime (I3MO) prevents vascular smooth muscle cell (VSMC) proliferation by selectively inhibiting signal transducer and activator of transcription 3 (STAT3). Looking for the underlying upstream molecular mechanism, we here reveal the important role of reactive oxygen species (ROS) for PDGF-induced… (More)
DOI: 10.1074/jbc.M113.489013

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Cite this paper

@inproceedings{Blaevi20131215LipoxygenaseCT, title={12/15-Lipoxygenase Contributes to Platelet-derived Growth Factor-induced Activation of Signal Transducer and Activator of Transcription 3*}, author={Tina Bla{\vz}evi{\'c} and Andrea V. Schwaiberger and Cornelia E. Schreiner and Daniel Schachner and Anja Schaible and Christoph S. Grojer and Atanas G Atanasov and Oliver Werz and Verena M. Dirsch and Elke Hannelore Heiss}, booktitle={The Journal of biological chemistry}, year={2013} }