12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo.

@article{Dioszeghy20081215LipoxygenaseRT,
  title={12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo.},
  author={Vincent Dioszeghy and Marcela Rosas and Benjamin H. Maskrey and Chantal Colmont and Nicholas Topley and Pavlos Chaitidis and Hartmut K{\"u}hn and Simon A Jones and Philip R. Taylor and Valerie B O'Donnell},
  journal={Journal of immunology},
  year={2008},
  volume={181 9},
  pages={6514-24}
}
The peritoneal macrophage (Mphi) is the site of greatest 12/15-lipoxygenase (12/15-LOX) expression in the mouse; however, its immunoregulatory role in this tissue has not been explored. Herein, we show that 12/15-LOX is expressed by 95% of resident peritoneal CD11b(high) cells, with the remaining 5% being 12/15-LOX(-). 12/15-LOX(+) cells are phenotypically defined by high F4/80, SR-A, and Siglec1 expression, and enhanced IL-10 and G-CSF generation. In contrast, 12/15-LOX(-) cells are a… CONTINUE READING