12(S)-hydroperoxyeicosatetraenoic acid (12-HETE) increases mitochondrial nitric oxide by increasing intramitochondrial calcium.

@article{Nazarewicz200712ShydroperoxyeicosatetraenoicA,
  title={12(S)-hydroperoxyeicosatetraenoic acid (12-HETE) increases mitochondrial nitric oxide by increasing intramitochondrial calcium.},
  author={Rafal Robert Nazarewicz and Woineshet J. Zenebe and Arti Parihar and Mordhwaj Singh Parihar and Michael Vaccaro and Cameron Rink and Chandan K. Sen and Pedram Ghafourifar},
  journal={Archives of biochemistry and biophysics},
  year={2007},
  volume={468 1},
  pages={114-20}
}
12(S)-hydroxyeicosatetraenoic acid (12-HETE) is one of the metabolites of arachidonic acid involved in pathological conditions associated with mitochondria and oxidative stress. The present study tested effects of 12-HETE on mitochondrial functions. In isolated rat heart mitochondria, 12-HETE increases intramitochondrial ionized calcium concentration that stimulates mitochondrial nitric oxide (NO) synthase (mtNOS) activity. mtNOS-derived NO causes mitochondrial dysfunctions by decreasing… CONTINUE READING

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