12(S)-HPETE induces itch-associated scratchings in mice.

  title={12(S)-HPETE induces itch-associated scratchings in mice.},
  author={Dae-Kwon Kim and Hyung-June Kim and Ki-Sa Sung and Hyuk Mun Kim and Sun-a Cho and Kwang-mi Kim and Chang-Hoon Lee and Jung-Ju Kim},
  journal={European journal of pharmacology},
  volume={554 1},
The itch-associated responses evoked by intradermal injection of 12(S)-HPETE and leukotriene B4 were compared in ICR-mice. 12(S)-HPETE and leukotriene B4 (0.01-0.2 nmol/site) induced scratching of the injected site, respectively; the dose-responses were a peak at 0.05 nmol/site (12(S)-HPETE) or 0.03 nmol/site (leukotriene B4). The scratching response by 12(S)-HPETE (0.05 nmol/site) started within 1 min, peaked in the first 10 min period, had almost subsided by 25 min whereas the effect of… CONTINUE READING