12(S)-HETE, pleiotropic functions, multiple signaling pathways.

@article{Szekeres200212SHETEPF,
  title={12(S)-HETE, pleiotropic functions, multiple signaling pathways.},
  author={Charles K Szekeres and Mohit Trikha and Kenneth V. Honn},
  journal={Advances in experimental medicine and biology},
  year={2002},
  volume={507},
  pages={509-15}
}
The arachidonic acid metabolite of 12 lipoxygenase, 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) promotes metastatic behavior of tumor cells (1). In this study we set out to identify 12(S)-HETE stimulated signaling pathways, and their contribution to cellular functions in A431 epidermoid carcinoma. 1) 12(S)-HETE signaling involves extracellular-regulated protein kinase (ERK1/2), protein kinase C (PKC), phosphatidylinositol 3-kinase (PI3 kinase) and Src kinase. 2) 12(S)-HETE stimulates cell… CONTINUE READING

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