11q13 amplification status and human papillomavirus in relation to p16 expression defines two distinct etiologies of head and neck tumours

@article{Ragin200611q13AS,
  title={11q13 amplification status and human papillomavirus in relation to p16 expression defines two distinct etiologies of head and neck tumours},
  author={Camille C Rose Ragin and Emanuela Taioli and Joel L. Weissfeld and Jaimie White and Karen M Rossie and Francesmary Modugno and Susanne M Gollin},
  journal={British Journal of Cancer},
  year={2006},
  volume={95},
  pages={1432 - 1438}
}
Two distinct etiologies of head and neck squamous cell carcinoma (HNSCC) have been proposed, DNA damage owing to tobacco and alcohol exposure and human papillomavirus (HPV) oncogene-mediated transformation. Common genetic alterations in HNSCC include TP53 mutations, 11q13 amplification (amp) and CDKN2A/p16 mutations or promoter methlyation. However, in HPV… CONTINUE READING