11beta-hydroxysteroid dehydrogenases: changing glucocorticoid action.

  title={11beta-hydroxysteroid dehydrogenases: changing glucocorticoid action.},
  author={Jonathan R Seckl},
  journal={Current opinion in pharmacology},
  volume={4 6},
11beta-hydroxysteroid dehydrogenases (11beta-HSDs) catalyse the interconversion of active cortisol and inert cortisone. Two isozymes have been discovered, each with unique properties and powerful biological roles. 11beta-HSD2 potently inactivates cortisol, protecting key tissues. By contrast, 11beta-HSD1 regenerates cortisol, amplifying its actions in liver, fat and brain. Overexpression of this isozyme may contribute to the pathogenesis of the metabolic syndrome. Its inhibition is a potential… CONTINUE READING
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