11beta-Hydroxysteroid dehydrogenase type 1 is an important regulator at the interface of obesity and inflammation.

@article{Staab201011betaHydroxysteroidDT,
  title={11beta-Hydroxysteroid dehydrogenase type 1 is an important regulator at the interface of obesity and inflammation.},
  author={Claudia A. Staab and Edmund Maser},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2010},
  volume={119 1-2},
  pages={56-72}
}
Systemic glucocorticoid excess, as exemplified by the Cushing syndrome, leads to obesity and all further symptoms of the metabolic syndrome. The current obesity epidemic, however, is not characterized by increased plasma cortisol concentrations, but instead comes along with chronic low-grade inflammation in adipose tissue and concomitant increased levels of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1, gene HSD11B1), a parameter known to cause obesity in a mouse model. 11beta-HSD1… CONTINUE READING