11C-labeled stilbene derivatives as Abeta-aggregate-specific PET imaging agents for Alzheimer's disease.

@article{Ono200311ClabeledSD,
  title={11C-labeled stilbene derivatives as Abeta-aggregate-specific PET imaging agents for Alzheimer's disease.},
  author={Masahiro Ono and A. D. Wilson and Jos{\'e} Nobrega and David Westaway and Paul Verhoeff and Zhiping Zhuang and M. -P. Kung and Hank F Kung},
  journal={Nuclear medicine and biology},
  year={2003},
  volume={30 6},
  pages={565-71}
}
A series of stilbene derivatives as potential diagnostic imaging agents targeting amyloid plaques in Alzheimer's disease (AD) were synthesized and evaluated. The syntheses of the stilbenes were successfully achieved by a simple Wadsworth-Emmons reaction between diethyl (4-nitrobenzyl)phosphonate and 4-methoxybenzaldehyde. 4-N,N-dimethylamino-4'-methyoxy and… CONTINUE READING