11C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas

@article{Park201511CPBR28II,
  title={11C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas},
  author={Eunkyung Park and J. Gallezot and Aracely Delgadillo and S. Liu and B. Planeta and Shu-Fei Lin and K. O’Connor and K. Lim and Jae-Yun Lee and Anne Chastre and Ming-Kai Chen and N. Seneca and D. Leppert and Y. Huang and R. Carson and D. Pelletier},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2015},
  volume={42},
  pages={1081-1092}
}
  • Eunkyung Park, J. Gallezot, +13 authors D. Pelletier
  • Published 2015
  • Medicine
  • European Journal of Nuclear Medicine and Molecular Imaging
  • PurposeActivated microglia play a key role in inflammatory demyelinating injury in multiple sclerosis (MS). Microglial activation can be measured in vivo using a positron emission tomography (PET) ligand 11C-PBR28. We evaluated the test-retest variability (TRV) and lesion detectability of 11C-PBR28 binding in MS subjects and healthy controls (HCs) with high-resolution PET.MethodsFour clinically and radiologically stable relapsing-remitting MS subjects (age 41 ± 7 years, two men/two women) and… CONTINUE READING
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