11C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas

@article{Park201511CPBR28II,
  title={11C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas},
  author={Eunkyung Park and Jean-Dominique Gallezot and Aracely Delgadillo and Shuang Liu and Beata M. Planeta and Shu-Fei Lin and Kevin C. O’Connor and Keunpoong Lim and Jeong-min Lee and Anne Chastre and Man Yin Chen and Nicholas Seneca and David Leppert and Yiyun Huang and Richard E. Carson and Daniel Pelletier},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2015},
  volume={42},
  pages={1081-1092}
}
Activated microglia play a key role in inflammatory demyelinating injury in multiple sclerosis (MS). Microglial activation can be measured in vivo using a positron emission tomography (PET) ligand 11C-PBR28. We evaluated the test-retest variability (TRV) and lesion detectability of 11C-PBR28 binding in MS subjects and healthy controls (HCs) with high-resolution PET. Four clinically and radiologically stable relapsing-remitting MS subjects (age 41 ± 7 years, two men/two women) and four HCs (age… CONTINUE READING
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from in vitro to in vivo

  • Q Guo, DR Owen, +4 authors humans et al. Quantifying the specific TSPO signal of C-1 healthy
  • International Symposium on Cerebral Blood flow…
  • 2015
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