11Beta-Hydroxysteroid Dehydrogenase Messenger Ribonucleic Acid Expression, Bioactivity and Immunoreactivity in Rat Cerebellum.

@article{Moisan199011BetaHydroxysteroidDM,
  title={11Beta-Hydroxysteroid Dehydrogenase Messenger Ribonucleic Acid Expression, Bioactivity and Immunoreactivity in Rat Cerebellum.},
  author={M.-P. Moisan and Jonathan R Seckl and Lawrence P. Brett and Carl Monder and Anil K. Agarwal and Perrin C White and Christopher R. W. Edwards},
  journal={Journal of neuroendocrinology},
  year={1990},
  volume={2 6},
  pages={
          853-8
        }
}
Abstract 11beta-Hydroxysteroid dehydrogenase (11beta-OHSD) metabolizes corticosterone to inactive 11-dehydrocorticosterone and thus protects non-specific mineralocorticoid receptors from exposure to corticosterone in the kidney in vivo. Clearly, 11beta-OHSD might also regulate corticosterone access to glucocorticoid receptors. We have investigated cerebellum, a tissue with high glucocorticoid receptor, but very low mineralocorticoid receptor levels and have shown marked 11beta-OHSD bioactivity… CONTINUE READING

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