Fever and results of CBC, platelets, CSF and blood culture were evaluated in 90 newborns admitted from home with possible sepsis. One group (Group 1-39 pts) had normal CBC, platelets and negative bacterial culture. A 2nd group (Group 11-13 pts) had proven septicemia (positive blood and/or CSF culture) and a 3rd group (Group III-38 pts) had clinical evidence of infection (bacterial or viral) but had negative bacterial culture. Mean BW, GA and age at readmission were similar between the groups. Fever was significantly higher in Group II compared to Group I (101.2±1.7 vs 100.0±1.0, p<0.05) but not different from Group III.The absolute band counts and I/T ratio did not distinguish Groups II and III. Initial fever of ≥101°F with elevated bands and I/T are sensitive indicators of serious neonatal infection warranting hospitalization. Conversely, infants without high fever and normal CEC can be managed without admission to the hospital.