111Indium Labelling of Recombinant Activated Coagulation Factor VII: In Vitro and Preliminary In Vivo Studies in Healthy Rats

@inproceedings{Nalla20121L,
  title={
111Indium Labelling of Recombinant Activated Coagulation Factor VII: In Vitro and Preliminary In Vivo Studies in Healthy Rats},
  author={Amarnadh Nalla and Inge Buch and Maibritt Sigvardt and Rasmus Poul Bodholdt and Andreas Kjaer and Birger Hesse},
  booktitle={International journal of molecular imaging},
  year={2012}
}
The aim of this study is to investigate whether (111)Indium-labelled recombinant FVIIa (rFVIIa) could be a potential radiopharmaceutical for localization of bleeding sources. DTPA-conjugated rFVIIa was radiolabelled with (111)In chloride. In vitro binding efficiency of (111)In-DTPA-rFVIIa to F1A2-Mab-sepharose was 99% in buffer, while it was 88-82% in serum… CONTINUE READING