111In-Cetuximab-F(ab′)2 SPECT and 18F-FDG PET for Prediction and Response Monitoring of Combined-Modality Treatment of Human Head and Neck Carcinomas in a Mouse Model

  title={111In-Cetuximab-F(ab′)2 SPECT and 18F-FDG PET for Prediction and Response Monitoring of Combined-Modality Treatment of Human Head and Neck Carcinomas in a Mouse Model},
  author={Laura K van Dijk and Otto C Boerman and Gerben M. Franssen and Johannes H.A.M. Kaanders and Johan Bussink},
  journal={The Journal of Nuclear Medicine},
  pages={287 - 292}
Treatment of head and neck squamous cell carcinomas with radiotherapy and the epidermal growth factor receptor (EGFR) inhibitor cetuximab shows an improved response in a subgroup of patients. The aim of this study was to noninvasively monitor treatment response by visualizing systemically accessible EGFR with 111In-cetuximab-F(ab′)2 while simultaneously evaluating tumor metabolism with 18F-FDG PET during combined-modality treatment. Methods: Eighty mice with patient-derived head and neck… 

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