11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study)

@article{Tiihonen200911yearFO,
  title={11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study)},
  author={Jari Tiihonen and Jouko L{\"o}nnqvist and Kristian Wahlbeck and Timo Klaukka and Leo Niskanen and Antti J Tanskanen and Jari K. Haukka},
  journal={The Lancet},
  year={2009},
  volume={374},
  pages={620-627}
}

Figures from this paper

Antipsychotic treatment and mortality in schizophrenia.

Among patients with schizophrenia, the cumulative antipsychotic exposure displays a U-shaped curve for overall mortality, revealing the highest risk of death among those patients with no antipsychotics use.

Comparative Effectiveness of Antipsychotic Drugs for Rehospitalization in Schizophrenia—A Nationwide Study With 20-Year Follow-up

Clozapine and LAIs are the most effective treatments in preventing psychiatric and all-cause hospitalization among chronic and first-episode patients with schizophrenia.

Mortality and non-use of antipsychotic drugs after acute admission in schizophrenia: A prospective total-cohort study

All-Cause Mortality and Medication Risk Factors in Schizophrenia: A Prospective Cohort Study

Patients with schizophrenia have higher mortality rates than normal controls and the type of antipsychotic and concomitant medication can affect mortality rates in schizophrenia.

20‐year follow‐up study of physical morbidity and mortality in relationship to antipsychotic treatment in a nationwide cohort of 62,250 patients with schizophrenia (FIN20)

The data suggest that long‐term antipsychotic use does not increase severe physical morbidity leading to hospitalization, and is associated with substantially decreased mortality, especially among patients treated with clozapine.
...

References

SHOWING 1-10 OF 37 REFERENCES

Effectiveness of antipsychotic treatments in a nationwide cohort of patients in community care after first hospitalisation due to schizophrenia and schizoaffective disorder: observational follow-up study

Patients treated with perphenazine depot, clozapine, or olanzapine have a substantially lower risk of rehospitalisation or discontinuation of their initial treatment than do patients treated with haloperidol, and the effectiveness of first and second generation antipsychotics varies greatly in the community.

Decline in the incidence of schizophrenia in Finnish cohorts born from 1954 to 1965.

The first nationwide historical cohort study of changes in the incidence of schizophrenia in Finland is reported, in which many of the previous methodological problems were overcome and the effect of cohort and period on the change was significant.

A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time?

In light of the potential for second-generation antipsychotic medications to further adversely influence mortality rates in the decades to come, optimizing the general health of people with schizophrenia warrants urgent attention.

Effectiveness of antipsychotic drugs in patients with chronic schizophrenia.

Olanzapine was the most effective in terms of the rates of discontinuation, and the efficacy of the conventional antipsychotic agent perphenazine appeared similar to that of quetiapine, risperidone, and ziprasidone.

Association of diabetes mellitus with use of atypical neuroleptics in the treatment of schizophrenia.

In this large group of patients with schizophrenia, receipt of a prescription for atypical neuroleptics was significantly associated with diabetes mellitus, and the prevalence of diabetes was significantly increased for patients who received clozapine, olanzapines, and quetiapins, but not risperidone.

Antidepressants and the risk of suicide, attempted suicide, and overall mortality in a nationwide cohort.

Among suicidal subjects who had ever used antidepressants, the current use of any antidepressant was associated with a markedly increased risk of attempted suicide and, at the same time, with a dramatically decreased risk of completed suicide and death.

A comparison of clinical and research DSM-III-R diagnoses of schizophrenia in a Finnish national birth cohort

Despite the official use of DSM-III-R nomenclature, it appears that the clinical concept of schizophrenia in Finland, manifest within the register, remains very restrictive.

Differential effects of risperidone, olanzapine, clozapine, and conventional antipsychotics on type 2 diabetes: findings from a large health plan database.

It is suggested that olanzapine, clozapine and some conventional antipsychotics appear to increase the risk of acquiring or exacerbating type 2 diabetes and that the effect may vary by drug.