11 beta-Hydroxysteroid dehydrogenases: key enzymes in determining tissue-specific glucocorticoid effects.

@article{Edwards199611BD,
  title={11 beta-Hydroxysteroid dehydrogenases: key enzymes in determining tissue-specific glucocorticoid effects.},
  author={Christopher R. W. Edwards and Rafn Benediktsson and Robert S. Lindsay and Jonathan R Seckl},
  journal={Steroids},
  year={1996},
  volume={61 4},
  pages={263-9}
}
Recent studies have demonstrated that the interconversion of active and inactive glucocorticoids plays a key role in determining the specificity of the mineralocorticoid receptor and controlling local tissue glucocorticoid receptor activation. Two distinct isoforms of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) have been identified. 11 beta-HSD1 is NADPH-dependent and at its major site of action (the liver) is a reductase, converting cortisone to cortisol (11… CONTINUE READING