11-Step Total Synthesis of Araiosamines

Total Synthesis of Araiosamines},
  author={Maoqun Tian and Ming Yan and Phil S Baran},
  booktitle={Journal of the American Chemical Society},
A concise route to a small family of exotic marine alkaloids known as the araiosamines has been developed, and their absolute configuration has been assigned. The dense array of functionality, high polarity, and rich stereochemistry coupled with equilibrating topologies present an unusual challenge for chemical synthesis and an opportunity for innovation. Key steps involve the use of a new reagent for guanidine installation, a remarkably selective C-H functionalization, and a surprisingly… CONTINUE READING
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This result does not rule out the possibility that the non-natural enantiomer accounts for the antibacterial activity

M. T. Villaume, E. Sella, G. Saul

Preparation of novel bis-indolic derivatives antibacterial drugs and a process for preparing them

J.-N. Denis, C. M. Jolivalt, M.M.L. Maurin, M. Jeanty
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For an elegant example of guanidine alkaloid synthesis via chemoselective C−H amination

R. E. Looper, T. J. Haussener, J.B.C.J. Org. Chem. Mack

This is clear from molecular models and an X-ray analysis of a closely related derivative, see SI for details

Chem. Soc

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