11-Step Total Synthesis of Araiosamines

@inproceedings{Tian201611StepTS,
  title={11-Step
Total Synthesis of Araiosamines},
  author={Maoqun Tian and Ming Yan and Phil S Baran},
  booktitle={Journal of the American Chemical Society},
  year={2016}
}
A concise route to a small family of exotic marine alkaloids known as the araiosamines has been developed, and their absolute configuration has been assigned. The dense array of functionality, high polarity, and rich stereochemistry coupled with equilibrating topologies present an unusual challenge for chemical synthesis and an opportunity for innovation. Key steps involve the use of a new reagent for guanidine installation, a remarkably selective C-H functionalization, and a surprisingly… CONTINUE READING
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