-11-Keto-boswellic acid derived amides: synthesis and cytotoxicity

  title={-11-Keto-boswellic acid derived amides: synthesis and cytotoxicity},
  author={Ratna Kancana Wolfram and Anja Barthel-Niesen and Renate Sch{\"a}fer and Lucie Heller and Ahmed Al-Harrasi and Ren{\'e} Csuk},
  journal={Mediterranean Journal of Chemistry},
The aim of this study was to prepare 11-keto-b-boswellic acid derivatives modified at C-24 and to evaluate their in vitro cytotoxicity. Acetyl-11-keto-b-boswellic acid (AKBA) was isolated from frankincense and transformed into 11-keto-b-boswellic acid (KBA). Both compounds served as starting materials for the synthesis of several amides or hydrazides. The derivatives were fully characterized, and their cytotoxicity was evaluated in vitro using sulforhodamine B (SRB) assays employing two human… Expand

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