11 Folding and Aggregation of Cu , Zn-Superoxide Dismutase

@inproceedings{Broom201711FA,
  title={11 Folding and Aggregation of Cu , Zn-Superoxide Dismutase},
  author={Helen R. Broom and Heather A. Primmer and Jessica A. O. Rumfeldt and Peter B Stathopulos and Kenrick A. Vassall and Y T Hwang and Elizabeth M. Meiering},
  year={2017}
}
1.1 ALS and SOD1 In 1993, a genetic link was established between amyotrophic lateral sclerosis (ALS) and mutant forms of Cu,Zn superoxide dismutase (SOD1) (Deng et al. 1993; Rosen et al. 1993), an antioxidant enzyme that catalyzes the dismutation of the damaging free radical superoxide anion (O2-) to hydrogen peroxide (H2O2) and diatomic oxygen (O2) via cyclic reduction and oxidation of a protein-bound Cu ion (Valentine et al. 2005). Today, over 150, predominantly missense mutations have been… CONTINUE READING
1 Citations
144 References
Similar Papers

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 144 references

Similar Papers

Loading similar papers…