11 Disparity between Bioactive and Immnoactive Luteinizing Hormone in Girls with Gonadal Dysgenesis: Effect of Estrogen Treatment

We have studied the ratio of bioactive to immunoactive (B/I) luteinizing hormone (LH) in eight girls with gonadal dysgenesis before and after estrogen replacement therapy with low doses of oral ethinyl estradiol. The estrogen suppression of bioactive LH, as measured by a rat interstitial cell testosterone assay (RICT), was more profound than the suppression… (More)