11 Beta-hydroxysteroid dehydrogenases in the brain: two enzymes two roles.

@article{Holmes200311BD,
  title={11 Beta-hydroxysteroid dehydrogenases in the brain: two enzymes two roles.},
  author={M C Holmes and Joyce L. W. Yau and Yuri V. Kotelevtsev and John J. Mullins and Jonathan R Seckl},
  journal={Annals of the New York Academy of Sciences},
  year={2003},
  volume={1007},
  pages={357-66}
}
Glucocorticoids affect a wide range of processes in the brain, altering neurotransmission, electrophysiological activity, metabolism, cell division, and death. These actions are mediated by corticosteroid receptors (glucocorticoid and mineralocorticoid) that modify transcriptional activity of target genes. The amount of steroid available to activate these receptors is not only dependent on the circulating levels but also on pre-receptor metabolism of glucocorticoids occurring intracellularly… CONTINUE READING