11β-Hydroxysteroid dehydrogenases and the brain: From zero to hero, a decade of progress

@inproceedings{Wyrwoll201111HydroxysteroidDA,
  title={11β-Hydroxysteroid dehydrogenases and the brain: From zero to hero, a decade of progress},
  author={Caitlin S. Wyrwoll and Maxx Holmes and Jonathan R Seckl},
  booktitle={Frontiers in Neuroendocrinology},
  year={2011}
}
Glucocorticoids have profound effects on brain development and adult CNS function. Excess or insufficient glucocorticoids cause myriad abnormalities from development to ageing. The actions of glucocorticoids within cells are determined not only by blood steroid levels and target cell receptor density, but also by intracellular metabolism by 11β-hydroxysteroid dehydrogenases (11β-HSD). 11β-HSD1 regenerates active glucocorticoids from their inactive 11-keto derivatives and is widely expressed… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 36 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 340 REFERENCES

Similar Papers

Loading similar papers…