11β-Hydroxysteroid dehydrogenase Type 1 in obesity and Type 2 diabetes

@article{Stulnig200311HydroxysteroidDT,
  title={11β-Hydroxysteroid dehydrogenase Type 1 in obesity and Type 2 diabetes},
  author={Thomas Michael Stulnig and Werner Waldh{\"a}usl},
  journal={Diabetologia},
  year={2003},
  volume={47},
  pages={1-11}
}
Obesity and Type 2 diabetes mellitus are associated with abnormal regulation of glucocorticoid metabolism that are highlighted by clinical similarities between the sequelae of insulin resistance and Cushing’s syndrome, as well as glucocorticoids’ functional antagonism to insulin. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activates functionally inert glucocorticoid precursors (cortisone) to active glucocorticoids (cortisol) within insulin target tissues, such as adipose tissue, thereby… CONTINUE READING