11β-Hydroxysteroid Dehydrogenase in the Brain: A Novel Regulator of Glucocorticoid Action?

@article{Seckl199711HydroxysteroidDI,
  title={11$\beta$-Hydroxysteroid Dehydrogenase in the Brain: A Novel Regulator of Glucocorticoid Action?},
  author={Jonathan R Seckl},
  journal={Frontiers in Neuroendocrinology},
  year={1997},
  volume={18},
  pages={49-99}
}
  • J. Seckl
  • Published 31 January 1997
  • Biology
  • Frontiers in Neuroendocrinology
Corticosteroids (glucocorticoids and mineralocorticoids) have multiple actions in the brain which are mediated via specific intracellular receptors. Recently, a novel and important control of glucocorticoid action has been identified in peripheral tissues; prereceptor metabolism by 11beta-hydroxysteroid dehydrogenase (11beta-HSD). This enzyme catalyses the conversion of the active glucocorticoids corticosterone and cortisol to inert 11 keto-products (11-dehydrocorticosterone, cortisone), thus… 
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