11,12,15-Trihydroxyeicosatrienoic acid mediates ACh-induced relaxations in rabbit aorta.

  title={11,12,15-Trihydroxyeicosatrienoic acid mediates ACh-induced relaxations in rabbit aorta.},
  author={William Campbell and Nancy Spitzbarth and Kathryn M. Gauthier and Sandra L. Pfister},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={285 6},
Rabbit aortic endothelium metabolizes arachidonic acid (AA) by the 15-lipoxygenase pathway to vasodilatory eicosanoids, hydroxyepoxyeicosatrienoic acids (HEETAs), and trihydroxyeicosatrienoic acids (THETAs). The present study determined the chemical identity of the vasoactive THETA and investigated its role in ACh-induced relaxation in the rabbit aorta. AA caused endothelium-dependent, concentration-related relaxations of the rabbit aorta. Increasing the extracellular KCl concentration from 4.8… CONTINUE READING


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