10t,12c-conjugated linoleic acid inhibits lipopolysaccharide-induced cyclooxygenase expression in vitro and in vivo Published, JLR Papers in Press, August 1, 2005. DOI 10.1194/jlr.M500064-JLR200

@article{Li200510t12cconjugatedLA,
  title={10t,12c-conjugated linoleic acid inhibits lipopolysaccharide-induced cyclooxygenase expression in vitro and in vivo Published, JLR Papers in Press, August 1, 2005. DOI 10.1194/jlr.M500064-JLR200},
  author={Guangming Li and David M. Barnes and Daniel E. Butz and Dale E. Bjorling and Mark E. Cook},
  journal={Journal of Lipid Research},
  year={2005},
  volume={46},
  pages={2134 - 2142}
}
Previous data demonstrated that conjugated linoleic acid (CLA) reduced eicosanoid release from select organs. We hypothesized that one active CLA isomer was responsible for the reduced prostaglandin release and that the mechanism was through the inhibition of inducible cyclooxygenase-2 (COX-2). Here, we examined the effects of 10t,12c-CLA and 9c,11t-CLA on COX-2 protein/mRNA expression, prostaglandin E2 (PGE2) production, and the mechanism by which CLA affects COX-2 expression and prostaglandin… Expand
CLA isomers inhibit TNFα-induced eicosanoid release from human vascular smooth muscle cells via a PPARγ ligand-like action
TLDR
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Conjugated Linoleic Acids Can Change Phagocytosis of Human Monocytes/Macrophages by Reduction in Cox-2 Expression
TLDR
Both CLA isomers increased macrophage phagocytosis through inhibition of Cox-2 expression (might by inactivation the NF-κB pathway) and the inhibition of PGE2 synthesis (by CLA treatment) enhanced the phagcytosis process in macrophages. Expand
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TLDR
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It is concluded that 10t, 12c-conjugated linoleic acid, 9t, 11t-con jugated linolesic acid and conjugated nonadecadienoic acid are platelet aggregation inhibitors while 9c, 11T-conugated linolenic acid is a moderate inhibitor and linoleanoid release, and 9 c, 11c- Conjugated Linoleic Acid has no effect on whole blood platelets aggregation. Expand
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A potential mechanism exists by which trans‐10, cis‐12 CLA and cis‐9, trans‐11 CLA may improve reproductive performance in dairy cows, by suppressing PGF2α synthesis in luteal cells via attenuation of COX‐2 gene expression. Expand
A dietary conjugated linoleic acid treatment that slows renal disease progression alters renal cyclooxygenase-2-derived prostanoids in the Han: SPRD-cy rat.
TLDR
The effects of CLA feeding onCOX2 protein levels and activity indicate that the beneficial effect of dietary CLA in this renal disorder is mediated in part via effects on COX2-derived prostanoids. Expand
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