10q23.3 loss of heterozygosity is higher in lymph node-positive (pT2-3,N+) versus lymph node-negative (pT2-3,N0) prostate cancer.

@article{Rubin200010q233LO,
  title={10q23.3 loss of heterozygosity is higher in lymph node-positive (pT2-3,N+) versus lymph node-negative (pT2-3,N0) prostate cancer.},
  author={Mark A. Rubin and Amy Gerstein and Kimberly Reid and David G. Bostwick and Liang Cheng and Ramon Parsons and Nickolas Papadopoulos},
  journal={Human pathology},
  year={2000},
  volume={31 4},
  pages={504-8}
}
Loss of heterozygosity (LOH) in the region of 10q23.3 has been associated with multiple tumors, including glioblastoma multiforme, melanoma, endometrial carcinoma, and prostate carcinoma. The tumor suppressor gene, PTEN/MMAC1, is also located in this region, and, in addition to other tumor types (eg, glioblastoma multiforme, endometrial, and melanoma), PTEN/MMAC1 mutations have been found in prostate cancer cell lines, xenografts, and hormone refractory prostate cancer tissue specimens. The aim… CONTINUE READING
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