107. Cognitive vulnerability to emotional disorders, self-regulation and pro-inflammatory state

@article{Swistun2012107CV,
  title={107. Cognitive vulnerability to emotional disorders, self-regulation and pro-inflammatory state},
  author={Dominika Swistun and C. L. Coe and Timothy J. Strauman and L. Y. Abramson},
  journal={Brain, Behavior, and Immunity},
  year={2012},
  volume={26}
}
microglia (Iba-1+/Arg+) from LPS–IL-4 mice. In LPS-injected mice, central IL-4 increased CCL2 mRNA, a chemokine that recruits macrophages to the injured CNS. Indeed, the LPS injected mice that received central IL-4 had highest percentage of macrophages (CD11b+/CD45hi) associated with the brain. Collectively, these results suggest that the increase in IL-4Ra on microglia serves to enhance microglial sensitivity to IL-4, which in turn, helps to promote a neuroprotective CNS environment. 

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[Cognitive vulnerability to depression].

Psychiatria polska • 2011
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