1031 Hemophiliac Immunodeficiency: Influence of Exposure to Factor Viii, Human T Leukemia Virus (htlv Iii) and Herpesviruses

We have evaluated 121 patients with hemophilia A for cellular immune defects and exposure to HTLV III, Epstein-Barr Virus (EBV) and cytomegalovirus (CMV). Immunoregulatory defects were found in the majority of the patients studied: decreased OKT.4/T.8 ratio, decreased lymphocyte proliferation in response to phytohemagglutinin (PHA), anti-immunoglobulin… CONTINUE READING