100 years of hyposensitization: history of allergen‐specific immunotherapy (ASIT)

  title={100 years of hyposensitization: history of allergen‐specific immunotherapy (ASIT)},
  author={J. Ring and Jan Gutermuth},
To cite this article: Ring J, Gutermuth J. 100 years of hyposensitization: history of allergen‐specific immunotherapy (ASIT). Allergy 2011; 66: 713–724. 
Specific immunotherapy with allergens: an important tool in the treatment of the allergic diseases
Immunotherapy is the only treatment that modifies the course of allergic diseases and depends on correct indications, use of standardized extracts and monitoring the therapeutic response.
Patient preferences for route of allergy immunotherapy: a comparison of four delivery methods
Allergen‐specific immunotherapy (IT) is a disease‐modifying treatment for allergic rhinitis, and adherence to the treatment schedule is important for a successful outcome. Several methods for
Modern aspects of hypersensitivity to stinging insects
The importance of pathogenetic treatment for this type of allergies is shown, as well as its solution via the creation of a new domestic drug, a bee venom allergoid, and its adoption into practical allergology.
Allergy: Concepts and Treatments
How an allergic reaction occurs is explored, as well as the causes of allergy and its treatments are discussed.
History of allergy in antiquity.
  • J. Ring
  • History
    Chemical immunology and allergy
  • 2014
Allergic diseases are not new. They have been described in the early medical literature in various cultures like Egypt, China, indigenous America and in the Greco-Roman tradition. The terms
Sublingual immunotherapy - Position paper prepared by Section of Immunotherapy, Polish Society of Allergy
There are no grounds for recommending SLIT in food allergy and, in view of the high safety profile and absence of anxiety-provoking infections, SLIT may be the method that is more often recommended.
Evolution of subcutaneous allergen immunotherapy (part 1): from first developments to mechanism-driven therapy concepts
Subcutaneous allergen immunotherapy is a long-established and well-documented treatment method for inhalant and insect venom allergies, with its efficacy and safety demonstrated in both the adult as well as in the pediatric population.
Allergoid preparations for allergen immunotherapy: A brief overview
Allergen immunotherapy (AIT) is now a well‐established therapy for allergic diseases by modifying the natural course of disease and changing the Th2 reaction toward Th1. Thus, AIT is a
Sublingual immunotherapy (SLIT)--indications, mechanism, and efficacy: Position paper prepared by the Section of Immunotherapy, Polish Society of Allergy.
The highest quality evidence supporting the efficacy of SLIT lasting 1-3 years has been provided by the large scale double-blind, placebo-controlled (DBPC) trials for grass pollen extracts, both in children and adults with allergic rhinitis.
Allergen‐specific immunotherapy: current concepts and future directions
This special issue of the journal takes the opportunity to evaluate the historical significance of allergen-specific immunotherapy, provide the most recent and current views on the immunological mechanisms, and critically appreciate the clinical aspects and evidence-based medicine.


The future of antigen-specific immunotherapy of allergy
  • R. Valenta
  • Medicine, Biology
    Nature Reviews Immunology
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This work indicates that the epitope complexity of natural allergen extracts can be recreated using recombinant allergens, and hypoallergenic derivatives of these can be engineered to increase treatment safety.
Heterogeneity of commercial timothy grass pollen extracts
Allergen extracts prepared from natural allergen sources are used for the diagnosis and specific immunotherapy of allergy.
Combination treatment with omalizumab and rush immunotherapy for ragweed-induced allergic rhinitis: Inhibition of IgE-facilitated allergen binding.
Studies in Specific Hypersensitiveness: IX. On the Phenomenon of Hyposensitization (the Clinically Lessened Sensitiveness of Allergy)
It is proposed to distinguish the lessened sensitiveness induced in allergy from the state of desensitization in anaphylaxis by designating the former condition as a state of hyposensItization.
Carbamylated monomeric allergoids as a therapeutic option for sublingual immunotherapy of dust mite- and grass pollen-induced allergic rhinoconjunctivitis: a systematic review of published trials with a meta-analysis of treatment using Lais® tablets.
It is suggested that SLIT using Lais® sublingual tablets is an effective and well-tolerated form of treatment.
Intralymphatic allergen administration renders specific immunotherapy faster and safer: A randomized controlled trial
In conclusion, intralymphatic allergen administration enhanced safety and efficacy of immunotherapy and reduced treatment time from 3 years to 8 weeks.
Sublingual immunotherapy for allergic rhinitis: systematic review and meta‐analysis *
The objective was to evaluate the efficacy of sublingual immunotherapy (SLIT), compared with placebo, for reductions in symptoms and medication requirements in allergic rhinitis.
Glutaraldehyde‐pollen‐tyrosine: clinical and immunological studies
The incidence of systemic reactions was reduced by the chemical treatment to negligible levels, permitting the therapeutic‐schedule to be reduced to three doses without impairment of clinical effectiveness.