100 years poliovirus: from discovery to eradication. A meeting report

  title={100 years poliovirus: from discovery to eradication. A meeting report},
  author={Tim Skern},
  journal={Archives of Virology},
  • T. Skern
  • Published 4 August 2010
  • Medicine
  • Archives of Virology
Just over hundred years ago, Karl Landsteiner and Erwin Popper identified a virus, later termed poliovirus, as the causative agent of poliomyelitis. This groundbreaking discovery simultaneously provided the basis for the measures that today prevent the outbreaks of the terrible epidemics caused by poliovirus. In 1988, the WHO started its eradication program to eliminate the virus from the planet. The symposium celebrated the discovery of poliovirus and discussed our current state of knowledge… 

Corrigendum to: Epidemic poliomyelitis, post-poliomyelitis sequelae and the eradication program

A novel, genetically stabilised OPV has been developed recently to stop the emergence and spread of cVDPV and OPV is being replaced by IPV in immunisation programs worldwide.

Epidemic poliomyelitis, post-poliomyelitis sequelae and the eradication program

A novel, genetically stabilised OPV has been developed recently to stop the emergence and spread of cVDPV and OPV is being replaced by IPV in immunisation programs worldwide.

Chapter 14 – Poliovirus

Polio Eradication in India

  • T. DholeV. Mishra
  • Biology
    Proceedings of the National Academy of Sciences, India Section B: Biological Sciences
  • 2011
The key to success lies in intelligent and imaginative use of the three OPVs, i.e. mOPV1, bOPV and tOPV, against WPV types 1 and 3, and circulating vaccine derived polio virus types 1, 2 and 3.

Unraveling the viral dark matter through viral metagenomics

Increased understanding of the viral dark matter will continue with a combination of cultivation, microscopy, sequencing, and bioinformatic efforts, which are discussed in the present review.

Evaluation des propriétés en culture de nouvelles souches atténuées de Poliovirus candidates à un nouveau vaccin inactivé

L'incidence de la poliomyelite, due a trois serotypes de Poliovirus, a considerablement diminue dans le monde grâce a l'utilisation systematique de deux types de vaccins : le vaccin

Importance of Selected Acute Flaccid Paralysis Diagnoses in an Emergency Department Setting for the Pediatric Population

Despite the seemingly intimidating diagnostic challenges of distinguishing various ailments under the umbrella of acute flaccid paralysis, the more potentially devastating but not as obvious diagnoses of Guillain-Barre syndrome and acute transverse myelitis should be considered with any reports in the pediatric patient of limb or sensory disorder.



Epidemiologic aspects of poliomyelitis eradication.

Although regional fade-outs of measles have occurred regularly during the seasonal low, measles is more frequently reintroduced because of its greater transmissibility, and it is suggested that this difference in reintroduction was a critical determinant of the difference between the eradicability of measles and poliomyelitis.

Public health. Type 2 poliovirus back from the dead in Nigeria.

Springing back to life from a weakened form of the pathogen used in a vaccine, poliovirus type 2 is causing a runaway outbreak in Nigeria, a stunning setback for the initiative, now already 9 years past its original deadline for vanquishing the virus.

Estimating the Extent of Vaccine-Derived Poliovirus Infection

Estimates of the extent of cVDPV circulation suggest widespread transmission in some countries, as might be expected from endemic wild poliovirus transmission in these same settings.

Vaccine-derived poliovirus (VDPV): Impact on poliomyelitis eradication.

Retrospective Analysis of a Local Cessation of Vaccination against Poliomyelitis: a Possible Scenario for the Future

A retrospective analysis of the cessation of OPV usage in a region of the Byelorussian Republic of the former Soviet Union in 1963 to 1966 is described, finding that a widespread circulation and evolution of independent lineages of vaccine-derived polioviruses took place in the region.

New Strategies for the Elimination of Polio from India

It is shown that high population density and poor sanitation cause persistence by not only facilitating transmission of poliovirus but also severely compromising the efficacy of the trivalent vaccine, and switching to monovalent vaccine may finally interrupt virus transmission.

The epidemiology of poliomyelitis: enigmas surrounding its appearance, epidemicity, and disappearance.

The eradication of poliomyelitis in spite of the fact that no more than 90% of US children have been reached indicates that either vaccine virus has spread to the unimmunized or a herd immunity effect is operating and the resultant disappearance of wild poliovirus prevents exposure of the unim immunized.

Changes in Population Dynamics during Long-Term Evolution of Sabin Type 1 Poliovirus in an Immunodeficient Patient

Poliovirus isolates from the immunodeficient patient evolved gradually toward non-temperature-sensitive and neurovirulent phenotypes, accumulating mutations at key nucleotide positions that correlated with the observed reversion to biological properties typical of wild polioviruses.


  • C. E. CordsJ. Holland
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1964
The present report demonstrates that the ribonucleic acid (RNA) of a drug-dependent poliovirus can be replicated by enzymes induced in HeLa cells through simultaneous infection with another (drug-independent) enterovirus.

Serologic response to inactivated poliovirus vaccine: a randomized clinical trial comparing 2 vaccination schedules in Puerto Rico.

The EPI schedule resulted in lower seroconversion rates for poliovirus types 1 and 2, relevant for tropical countries planning to use IPV in a posteradication environment.