10-formyltetrahydrofolate dehydrogenase-induced c-Jun-NH2-kinase pathways diverge at the c-Jun-NH2-kinase substrate level in cells with different p53 status.

@article{Ghose200910formyltetrahydrofolateDC,
  title={10-formyltetrahydrofolate dehydrogenase-induced c-Jun-NH2-kinase pathways diverge at the c-Jun-NH2-kinase substrate level in cells with different p53 status.},
  author={Sampa Ghose and Natalia Oleinik and Natalia I Krupenko and Sergey A Krupenko},
  journal={Molecular cancer research : MCR},
  year={2009},
  volume={7 1},
  pages={99-107}
}
10-Formyltetrahydrofolate dehydrogenase (FDH) suppresses cancer cell proliferation through p53-dependent apoptosis but also induces strong cytotoxicity in p53-deficient prostate cells. In the present study, we have shown that FDH induces apoptosis in PC-3 prostate cells through simultaneous activation of the c-Jun-NH(2)-kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways with JNK phosphorylating c-Jun and ERK1/2 phosphorylating Elk-1. The JNK1/2 inhibitor SP600125 or ERK1/2… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 59 references

and synergism with interferon - a signalling

  • SY Fuchs, L Dolan, RJ Davis, Z Ronai
  • 2007

induced by capsaicin in prostate PC - 3 cells involves ceramide accumulation , neutral sphingomyelinase , and JNK activation

  • G Li, Y Xiang, K Sabapathy, RH Silverman
  • Apoptosis
  • 2007

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