10-Step Asymmetric Total Synthesis and Stereochemical Elucidation of (+)-Dragmacidin D.

@article{Jackson201510StepAT,
  title={10-Step Asymmetric Total Synthesis and Stereochemical Elucidation of (+)-Dragmacidin D.},
  author={Jeffrey J. Jackson and Hiroyuki Kobayashi and Sophia D Steffens and Armen Zakarian},
  journal={Angewandte Chemie},
  year={2015},
  volume={54 34},
  pages={9971-5}
}
The asymmetric synthesis of dragmacidin D (1) was completed in 10 steps. Its sole stereocenter was set by using direct asymmetric alkylation enabled by a C2-symmetric tetramine and lithium N-(trimethylsilyl)-tert-butylamide as the enolization reagent. A central Larock indole synthesis was employed in a convergent assembly of the heterocyclic subunits. The… CONTINUE READING