10-Hydroxy-8(Z)-octadecenoic acid, an intermediate in the bioconversion of oleic acid to 7,10-dihydroxy-8(E)-octadecenoic acid
@article{Hou200510Hydroxy8ZoctadecenoicAA,
title={10-Hydroxy-8(Z)-octadecenoic acid, an intermediate in the bioconversion of oleic acid to 7,10-dihydroxy-8(E)-octadecenoic acid},
author={Ching Tsang Hou and Marvin O. Bagby},
journal={Journal of Industrial Microbiology},
year={2005},
volume={9},
pages={103-107}
}SummaryPreviously, we reported the discovery of a new compound, 7,10-dihydroxy-8(E)-octadecenoic acid (DOD) which was produced from oleic acid by a new bacterial isolate PR3 [6,7]. The reaction is unique in that it involves a hydroxylation at two positions and a rearrangement of the double bond of the substrate molecule. Now, we have isolated another compound from the reaction mixture determined by GC/MS to be 10-hydroxy-8-octadecenoic acid (HOD). NMR and IR data indicate that the unsaturation…
23 Citations
Production of 10-Hydroxy-8(E)-Octadecenoic Acid from Oleic Acid Conversion by Strains of Pseudomonas aeruginosa
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This study has identified a high-yielding P. aeruginosa strain and provided the reaction characteristics needed to develop a scale-up production process of HOD for testing its properties and potential new uses.
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Results from this study demonstrated that natural vegetable oils, without being intentionally hydrolyzed, could be used as efficient substrates for the microbial production of value-added hydroxy fatty acids.
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Lyophilized non-proliferating microbial cells of Pseudomonas sp. 42A2 showed their ability to catalyze the bioconversion of oleic acid into (E)-10-hydroxy-8-octadecenoic acid (MHOD) and (E)-…
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SummaryPreviously, we reported the isolation of a new microbial strain,Flavobacterium sp. DS5 (NRRL B-14859) which converted oleic and linoleic acids to their corresponding 10-keto- and…
Factors Influencing the Production of a Novel Compound, 7,10-Dihydroxy-8(E)-octadecenoic Acid, by Pseudomonas aeruginosa PR3 (NRRL B-18602) in Batch Cultures
- Biology, EngineeringCurrent Microbiology
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This is the first report on a successful scale-up production of DOD, which converts oleic acid to a novel compound, 7,10-dihydroxy-8(E)-octadecenoic acid (DOD), in batch cultures using Fernbach flasks and a bench-top bioreactor.
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