10-Acetylirciformonin B, A Sponge Furanoterpenoid, Induces DNA Damage and Apoptosis in Leukemia Cells

@article{Su201210AcetylirciformoninBA,
  title={10-Acetylirciformonin B, A Sponge Furanoterpenoid, Induces DNA Damage and Apoptosis in Leukemia Cells},
  author={Jui Hsin Su and Wen-Been Chang and Huei-Mei Chen and Mohamed El‐Shazly and Ying-Chi Du and Ting-Hsuan Kung and Yu-Cheng Chen and Ping-Jyun Sung and Yuan-Shing Ho and F W Kuo and Mei-Chin Lu},
  journal={Molecules},
  year={2012},
  volume={17},
  pages={11839 - 11848}
}
10-Acetylirciformonin B, a furanoterpenoid derived from irciformonin B found in a marine sponge, has been reported to possess potent cytotoxic activity against several cancer cell lines. However, the mechanism of its apoptotic activity against human leukemia cells has never been reported. The purpose of this study was to investigate the cytotoxic effects of 10-acetylirciformonin B and its possible mechanism of action against leukemia HL 60 cells. We found that 10-acetylirciformonin B decreased… 

Figures from this paper

Cracking the Cytotoxicity Code: Apoptotic Induction of 10-Acetylirciformonin B is Mediated through ROS Generation and Mitochondrial Dysfunction
TLDR
10AB-induced apoptosis is mediated through the overproduction of ROS and the disruption of mitochondrial metabolism, suggesting that ROS overproduction plays a crucial rule in the cytotoxic activity of 10AB.
Induction of apoptosis by Aaptos sp., fractions in human breast cancer cell line, MCF-7
TLDR
MCF-7 cell death exerted by the fraction was found to be mediated by apoptosis based on the exposure of phosphatidylserine and presence of DNA fragmentation in treated cells, suggesting bioactive compounds present in these fractions are responsible in inducing apoptosis and thus, possessed potential to be candidates for chemotherapeutic drugs.
New Drugs from the Sea: Pro-Apoptotic Activity of Sponges and Algae Derived Compounds
TLDR
This review will focus on some selected bioactive molecules from sponges and algae with pro-apoptotic potential in tumour cells.
Apoptosis induction on human breast cancer T47D cell line by extracts of Ancorina sp.
TLDR
Methanol crude extract has high efficacy to induce apoptosis through caspase-3 activation compared to the other extracts, Hence methanol extract warrants further investigation as a natural medicine for human breast cancer.
Apoptosis induction on human breast cancer T47D cell line by extracts of Ancorina sp.
TLDR
Methanol crude extract has high efficacy to induce apoptosis through caspase-3 activation compared to the other extracts, Hence methanol extract warrants further investigation as a natural medicine for human breast cancer.
Anticancer secondary metabolites from marine sponges Deniz süngerlerinden antikanser metabolitler
The oceans cover 70% of the Earth’s surface. The marine environment is an important source of secondary metabolites with high biodiversity. Besides other marine species, sponges with a wide range of
Natural Products from Sponges
TLDR
Development of recombinant microorganisms engineered for efficient production of sponge-derived products is a promising strategy that deserves further attention in future investigations in order to address the limitations regarding sustainable supply of marine drugs.
Cytotoxic Compounds Derived from Marine Sponges. A Review (2010–2012)
TLDR
Petrosia, Haliclona (Haplosclerida), Rhabdastrella (Tetractinellida), Coscinoderma and Hyppospongia (Dictyioceratida), were found to be the most promising genera because of their capacity for producing new bioactive compounds.
Reactive Oxygen Species and Autophagy Modulation in Non-Marine Drugs and Marine Drugs
TLDR
This review describes the strategy of oxidative stress-based therapy and connects the ROS modulating effect to the regulation of apoptosis and autophagy and focuses on exploring the function and mechanism of cancer therapy by the Autophagy modulators including inhibitors and inducers from non-marine drugs and marine drugs.
A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2011
TLDR
This report aims to review 42 compounds of marine origin and their derivatives that were published in 2011 as promising anticancer compounds that are still in use and represent a renewed hope for cancer therapy.
...
...

References

SHOWING 1-10 OF 24 REFERENCES
Antrodia camphorata in submerged culture protects low density lipoproteins against oxidative modification.
TLDR
The findings suggest that the antioxidant properties of Antrodia camphorata may also provide effective protection from atherosclerosis.
Antibacterial Bisabolane-Type Sesquiterpenoids from the Sponge-Derived Fungus Aspergillus sp.
TLDR
Four new bisabolane-type sesquiterpenoids, aspergiterpenoid A, 1, 2, 3, and 4 showed selective antibacterial activity against eight bacterial strains with the MIC values between 1.25 and 20.0 µM and the cytotoxic, antifouling, and acetylcholinesterase inhibitory activities of these compounds were examined.
Cytotoxic C21 and C22 terpenoid-derived metabolites from the sponge Ircinia sp.
TLDR
Among these metabolites, 2 is the first C21 terpenoid-derived metabolite to be reported from this genus, and exhibited significant cytotoxic activity against K562, DLD-1, HepG2, and Hep3B cancer cell lines.
Reactive Oxygen Species: A Breath of Life or Death?
TLDR
Recent work in ROS-mediated signaling in cancer cells and its potential as a target for developmental therapeutics is covered.
Towards Commercial Production of Sponge Medicines
TLDR
The current state of sponge metabolite production is discussed and the steps that need to be taken to develop commercial production techniques are discussed.
DNA breakage and cell cycle checkpoint abrogation induced by a therapeutic thiopurine and UVA radiation
TLDR
It is shown that the interaction between low doses of UVA and an immunosuppressant drug causes photochemical DNA lesions, including DNA breaks, and can compromise cell cycle checkpoints, which could contribute to the high risk of sunlight-related skin cancer in long-term Immunosuppressed patients.
Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways
TLDR
N nanoparticles and reactive oxidative species induce DNA damage, activating p53 and proteins related to DNA repair, mimicking irradiation-related carcinogenesis pathways.
ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response
TLDR
It is suggested that ATM and its kinase activity are essential for the TSA-induced regulation of gene expression and are important in helping to design combinatory treatment schedules for anticancer radio- or chemo-therapy with HDAC inhibitors.
...
...