1-beta-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells.

@article{Strum19941betaDArabinofuranosylcytosineSC,
  title={1-beta-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells.},
  author={Jay C. Strum and George W Small and Susan B. Pauig and Larry W. Daniel},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 22},
  pages={15493-7}
}
The effect of 1-beta-D-arabinofuranosylcytosine (ara-C) on phospholipid metabolism was investigated in HL-60 cells. Treatment of cells with ara-C resulted in a time- and dose-dependent increase in the mass of ceramide and diglyceride. When cells were treated with 10 microM ara-C, an increase in the mass of ceramide and diglyceride was detectable at 5 min and reached a plateau at 30 min with a 2-fold increase compared to control cells. Treatment of cells with 10 microM ara-C resulted in the… CONTINUE READING