1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents.

@article{Cooper20171Thiazol2ylN3methyl1Hpyrozole5carbo,
  title={1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents.},
  author={Alan B. Cooper and Stephane Ciblat and Gerald W. Shipps and Jedd F. Levine and Matthew Kostura and Vibha B. Oza and L{\'e}a Constantineau-Forget and Martin D{\'e}ry and Chantal Grand-Ma{\^i}tre and Nicolas Bruneau-Latour and {\'E}dith Bellavance and Michael A. Patane and Arshad M Siddiqui and Michael Luther},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2017},
  volume={27 18},
  pages={
          4471-4477
        }
}

Pharmacological activation of the mitochondrial stress protease OMA1 reveals a therapeutic liability in Diffuse Large B-Cell Lymphoma

BTM-3566 represents a first- of-its kind approach of selectively hyperactivating the mitochondrial ISR for treating DLBCL and identifies the mitochondrial protein FAM210B as a negative regulator of B TM-3528 and BTM- 3566 activity.

Targeting aggressive B-cell lymphomas through pharmacological activation of the mitochondrial protease OMA1

(140/150 words) Constitutive activation of the ATF4-mediated integrated stress response (ATF4-ISR) is common in cancer and buffers the metabolic challenges imposed by rapid proliferation. However,

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