1 Thermodynamic and Computational Studies on the Binding of p 53-Derived Peptides and Peptidomimetic Inhibitors to HDM 2

@inproceedings{Grsslin20091TA,
  title={1 Thermodynamic and Computational Studies on the Binding of p 53-Derived Peptides and Peptidomimetic Inhibitors to HDM 2},
  author={Anja Gr{\"a}sslin and C{\'e}line Amoreira and Kim K. Baldridge and John Alan Robinson},
  year={2009}
}
Helix power: The binding interactions of linear and constrained beta-hairpin-shaped peptides with HDM2 were compared by using experimental and theoretical methods. The entropic advantages enjoyed by the constrained peptides were found to be largely offset by reduced enthalpic contributions to binding of the cyclic mimetics. Formation of hydrogen bonds upon helix folding could contribute significantly to the enhanced enthalpy observed in binding of the linear peptides.The human double minute 2… CONTINUE READING