1 S-Phase Synchronization Facilitates the Early Progression of 2 Induced-Cardiomyocyte Reprogramming through Enhanced Cell-Cycle Exit 3 4

@inproceedings{Bektik20181SS,
  title={1 S-Phase Synchronization Facilitates the Early Progression of 2 Induced-Cardiomyocyte Reprogramming through Enhanced Cell-Cycle Exit 3 4},
  author={Emre Bektik and Adrienne T. Dennis and Gary Pawlowski and Danielle Maleski and Shinya Takahashi and Kenneth R Laurita and Isabelle Desch{\^e}nes and Ji-Dong Fu},
  year={2018}
}
Direct reprogramming of fibroblasts into induced cardiomyocytes (iCMs) holds a great 16 promise for regenerative medicine and has been studied in several major directions. However, 17 cell-cycle regulation, a fundamental biological process, has not been investigated during 18 iCM-reprogramming. Here, our time-lapse imaging on iCMs, reprogrammed by Gata4, Mef2c, and 19 Tbx5 (GMT) monocistronic retroviruses, revealed that iCM-reprogramming was majorly initiated 20 at late-G1or S-phase and nearly… CONTINUE READING

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