1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages

@article{Biedro20081MethylnicotinamideAN,
  title={1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages},
  author={R. Biedroń and M. Ciszek and M. Tokarczyk and M. Bobek and M. Kurnyta and E. Słomińska and R. Smolenski and J. Marcinkiewicz},
  journal={Archivum Immunologiae et Therapiae Experimentalis},
  year={2008},
  volume={56},
  pages={127 - 134}
}
Introduction:1-Methylnicotinamide (MNA), a major metabolite of nicotinamide (NA), is known to exert anti-inflammatory effects in vivo. Treatment of inflammatory skin diseases by topical application of MNA provides certain advantages over the use of NA. However, in contrast to NA, the molecular mechanisms of the anti-inflammatory properties of MNA are not well known. In this study the influence of exogenous MNA and NA in vivo on the generation of inflammatory mediators by macrophages (Mϕ) was… Expand
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  • 2010
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