1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3.

@article{Shang20031Methyl4phenylpyridiniumAI,
  title={1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3.},
  author={Tiesong Shang and Alexander V Uihlein and Jennifer Van Asten and Balaraman Kalyanaraman and Cecilia J. Hillard},
  journal={Journal of neurochemistry},
  year={2003},
  volume={85 2},
  pages={358-67}
}
1-Methyl-4-phenylpyridinium (MPP+), the toxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, induces apoptosis in cerebellar granule neurons (CGNs). We have tested the hypothesis that organic cation transporter (OCT) 3 mediates the accumulation and, hence, the toxicity of MPP+ in CGNs. CGNs in primary culture express OCT3 but do not express mRNA for OCT1, OCT2 or the dopamine transporter. Cerebellar astrocytes are negative for OCT3 protein by immunocytochemistry. [3H]MPP… CONTINUE READING

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