1-Methyl-4-phenyl-pyridinium (MPP+) uptake does not explain the differential toxicity of MPP+ in the nigrostriatal and mesolimbic dopaminergic pathways

@article{Hung19951Methyl4phenylpyridiniumU,
  title={1-Methyl-4-phenyl-pyridinium (MPP+) uptake does not explain the differential toxicity of MPP+ in the nigrostriatal and mesolimbic dopaminergic pathways},
  author={H. C. Hung and P. L. Tao and Eminy H Y Lee},
  journal={Neuroscience Letters},
  year={1995},
  volume={196},
  pages={93-96}
}
  • H. C. Hung, P. L. Tao, Eminy H Y Lee
  • Published in Neuroscience Letters 1995
  • Biology, Medicine
  • The present study examined the possible differential toxicity of 1-methyl-4-phenyl-pyridinium (MPP+) in the nigrostriatal and mesolimbic dopaminergic pathways in BALB/c mice, and investigated whether MPP+ uptake may account for this differential toxicity. Results indicated that chronic MPP+ infusions to the striatum (ST) and nucleus accumbens (NAc) both produced a toxicity on dopamine (DA) neurons. However, MPP+ produced a more severe DA depletion in the ST than in the NAc. Kinetic analyses… CONTINUE READING

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