1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2.

  title={1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2.},
  author={Liu Yang and Russell Thomas Matthews and J{\"o}rg Bernhard Schulz and Thomas Klockgether and Adolfo W Liao and J C Martinou and John B. Penney and Bradley T. Hyman and Michael Beal},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={18 20},
The proto-oncogene Bcl-2 rescues cells from a wide variety of insults. Recent evidence suggests that Bcl-2 protects against free radicals and that it increases mitochondrial calcium-buffering capacity. The neurotoxicity of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyride (MPTP) is thought to involve both mitochondrial dysfunction and free radical generation. We therefore investigated MPTP neurotoxicity in both Bcl-2 overexpressing mice and littermate controls. MPTP-induced depletion of dopamine and… CONTINUE READING
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