1-Chloro-2-formyl indenes and tetralenes as antitubercular agents.

Abstract

1-Chloro-2-formyl indenes and tetralenes have been synthesized using Vilsmeier-Haack-Arnold reaction onto indanones and tetralones. Most of these analogues exhibited antitubercular activity against Mycobacterium tuberculosis H37Rv strain with MICs ranging from 30 to 500 μg/mL. Analogue 13 was further modified to some derivatives. The most active analogue 23… (More)
DOI: 10.1016/j.bmcl.2011.05.016

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