1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta.

@article{Kunick20041AzakenpaulloneIA,
  title={1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta.},
  author={Conrad Kunick and Kathrin Lauenroth and Maryse Leost and Laurent Meijer and Thomas Lemcke},
  journal={Bioorganic & medicinal chemistry letters},
  year={2004},
  volume={14 2},
  pages={413-6}
}
Kenpaullone derivatives with a modified parent ring system were synthesized in order to develop kinase inhibitors with enhanced selectivity. Among the novel structures, 1-azakenpaullone was found to act as a selective GSK-3beta versus CDK1 inhibitor. The charge distribution within the 1-azakenpaullone molecule is discussed as a possible explanation for the… CONTINUE READING